EFFECT OF TAMOXIFEN ON SERUM-CHOLESTEROL AND LIPOPROTEINS DURING CHEMOHORMONAL THERAPY

Citation
Am. Dnistrian et al., EFFECT OF TAMOXIFEN ON SERUM-CHOLESTEROL AND LIPOPROTEINS DURING CHEMOHORMONAL THERAPY, Clinica chimica acta, 223(1-2), 1993, pp. 43-52
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Medicinal
Journal title
ISSN journal
0009-8981
Volume
223
Issue
1-2
Year of publication
1993
Pages
43 - 52
Database
ISI
SICI code
0009-8981(1993)223:1-2<43:EOTOSA>2.0.ZU;2-F
Abstract
The effect of tamoxifen on serum cholesterol, high density lipoprotein cholesterol (HDL-cholesterol), low density lipoprotein cholesterol (L DL-cholesterol) and the ratio of LDL-cholesterol to HDL-cholesterol (L DL-C/HDL-C) was investigated in breast cancer patients undergoing ther apy for advanced disease. Longitudinal studies in 24 patients treated with tamoxifen (10 mg, twice daily) indicated average decreases in tot al serum cholesterol (17%) and LDL-cholesterol (27%), whereas the effe ct of tamoxifen on HDL-cholesterol varied with the individual patient. There was a significant decrease in the LDL-C/HDL-C ratio (33%) consi stent with a decreased risk for coronary artery disease. This benefici al influence of tamoxifen on risk factors associated with cardiovascul ar disease was evident in both premenopausal and postmenopausal patien ts whether tamoxifen was administered alone or in combination with cyt otoxic chemotherapy.