SPECIFICITY OF AUTOANTIBODIES AGAINST OXIDIZED LDL AS AN ADDITIONAL MARKER FOR ATHEROSCLEROTIC RISK

Citation
E. Maggi et al., SPECIFICITY OF AUTOANTIBODIES AGAINST OXIDIZED LDL AS AN ADDITIONAL MARKER FOR ATHEROSCLEROTIC RISK, Coronary artery disease, 4(12), 1993, pp. 1119-1122
Citations number
13
Language
INGLESE
art.tipo
Note
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
ISSN journal
0954-6928
Volume
4
Issue
12
Year of publication
1993
Pages
1119 - 1122
Database
ISI
SICI code
0954-6928(1993)4:12<1119:SOAAOL>2.0.ZU;2-F
Abstract
Background: LDL oxidation is a crucial step in the development and pro gression of atherosclerotic lesions. The detection of an increase in t he anti-oxidized LDL antibody titre may thus represent a biological ma rker of enhanced LDL oxidation in vivo. Methods: The occurrence of ant i-oxidized LDL autoantibodies was investigated in control patients, in patients with atherosclerotic coronary artery disease, in those witho ut clinically relevant signs of atherosclerosis, but considered at ris k, and in patients with chronic alcohol-related liver disease. Results : Anti-oxidized LDL autoantibodies were present in the plasma of the m ajority of patients with overt coronary atherosclerosis. An increased antibody titre can also be detected well before the onset of clinicall y relevant signs of the atherosclerotic disease in patients classicall y considered at risk, indicating the occurrence of in-vivo LDL oxidati on during atherosclerosis development. The specificity of molecular ta rgets (LDL) for oxidative modifications is supported by the demonstrat ion that anti-oxidized LDL autoantibodies are absent in the plasma of alcoholic patients who exhibit a marked increase in biological markers of oxidative stress but do not classically develop atherosclerosis. C onclusion: These data demonstrate that the occurrence of anti-oxidized LDL autoantibodies could be specifically related to the promotion and progression of atherosclerosis and is not a simple epiphenomenon of a ny oxidative process occurring in vivo.