USE OF PSYCHOTROPIC-DRUGS DURING PREGNANCY - A REPORT OF THE INTERNATIONAL COOPERATIVE DRUG-USE IN PREGNANCY (DUP) STUDY

Authors
MARCHETTI F ROMERO M BONATI M TOGNONI G BONATI M TOGNONI G MIGLIO D NIGRO M BALOCCO R BORTOLUS R DAPSY I MARCHETTI F ROMERO M COLOMBO F FELLIN G MARFISI RM NEGRELLO I OLIVIERI M BATISTA MDDD SATO A BARROS JCR LEONE CR CURY M ZULLINI MT MATERASSI P KLOTZEL D PEREIRA JCR GANDOLFI E CARVALHO ML PEREIRA VLM MARETTI M ESCALER MM LIPPI UG ARNAZI PV CASANOVA LD BATISTA NA GARCIA SL DEFREITAS E GIANATTASIO F ALMEIDA ACD COSTA MF SADECK LDR RIVOREDO CR MATAMOROS AC CULIG J KRISKA M HRKOVA V MRAZEK M NOVARIK J BLAAKAER J PHILIP J OBEL E HEMMINKI E HOFFMANNTRAEGER A TEICHERT B PEIKER G REIMANN I JAGER O OFORIADJEI D THOMAS M UPPAL R OHERLIHY C COLLE G FAILLI C LINCIANO M COMOTTI S LEIDI G ANTONINI E PIZZURRO V VECCHIONE A BASEVI V CAPOZZI A CRESCINI C AGOSTI S CORRAO G QUARANTA S RAVASI L RUSPI G SPINA GF VIGNATI A PELLINI M LONDERO F ORTI CD BORSATTO M BRIGATO G GRELLA P CELLANI F GROSSI F TUDISCO A PALMERIO G STEVENAZZI G TOMASSI A MASSOBRIO M MENATO G ZAMBELLI G PINTO P BRESSAN G CARLINO A COLOMBO PA MIGLIETTA P ROSSI V MARTINELLI P DILAZZARO A BERTULETTI P CAVADINI R LOMBARDI PL DESENA C MARSONI V DELFAVERO A VENTURA F NARDUCCI U AZZALINI B PINTO A PETRELLI A LUERTI M FANELLI A MARIUCCI A COLAVITA D CUCCHIA G MARGIACCHI P MARCHETTI S ANGIOLILLO M GENTILE E CESARATTO A DANDREA O DIPASQUALE R ANGELI G SETTONCE S ORMANDO A ZELANTE L PICCOTTO G TORRIOLI D PAPA E PALOMBARO G MASCELLANTI P DIFRANCESCO A LOREFICE R ANGELONI C DECAROLIS AM BALUCANI M DAURIZIO MD PETRICONE G TATA R LICATA F TAMBURINI M SELVA S CALDERALE L RIGONI I STELLA G RADAELLI R PASSERELLI G ALBONI A SANTARELLI P IEZZI E PONTE B DEMATTIA A LANZASILVERI C YOSHIOKA H SHIMIZU T FUJITA K KAKUYA F ITO S NAMBU H IWASAKI K TAKEDA Y AKERA T KANEKO K MASUMURA C SEKI E MUKUBO M MATSUDA I TSUNAWAKI T KIYOTA Y MIYAZAKI Y IKENOUE T NAKAYAMA M INAFUKU Y VENTURA CS GRECH ES HARDEN H MATHESON I BERGSJO P PEEN A NESHEIM BI LEE D STANULOVIC M SABO A DIOGENE E LAPORTE JR ARAGON C VIDAL X FARRE M LLORENTE M CASES CG MARTI A GRAU C PALMA C MARTINEZ J ROMERO AS SANCHEZ CF NOGUES J NOTIVOL R SALVA R MOTA C MORILLAS MG LAFUENTE L ORTIZ J ARENILLAS MG DELOLMO TM LOPO CR FRIAS J LUCENA MI RIVERA RR TRISTAN C HONORATO J SACRISTAN JA MEDIAVILLA A TORELLO J SERRANO MI HERNANDEZ JAG OCON L CUENA R DEVELASCO JMG HERNANDEZ G ESPLUGUES J SINUES B MEMBRADO J WEERASINGHE T FERNANDO G SODERMAN P BLOMQVIST KH DEJONGVANDEBERG L WAARDENBURG M BENNETT P GRANT A REID W JACKSON A MCGARRY JA MCLEAN MW HULSE M CAMERON S DUFFY S VINALL P BIBBY J ELLIOT B DEXTER J USHERWOOD M TEBBUTT H BLIGH GM KILLICK S HIRSCH P WINGFIELD W BOBER SA BULLOUGH C HALL M FISHER A KASILO O NYAZEMA N
Citation
F. Marchetti et al., USE OF PSYCHOTROPIC-DRUGS DURING PREGNANCY - A REPORT OF THE INTERNATIONAL COOPERATIVE DRUG-USE IN PREGNANCY (DUP) STUDY, European Journal of Clinical Pharmacology, 45(6), 1993, pp. 495-501
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
0031-6970
Volume
45
Issue
6
Year of publication
1993
Pages
495 - 501
Database
ISI
SICI code
0031-6970(1993)45:6<495:UOPDP->2.0.ZU;2-E
Abstract
Drug Use in Pregnancy (DUP) is an international epidemiological survey of drug use in pregnancy conducted from 1988 to 1990 in 148 maternity wards, representing the general delivery practices of 22 countries. D ata on exposure of pregnant women to psychotropic drugs, the indicatio ns for their use and their correlation with maternal characteristics a re reported. Of the 14,778 women interviewed, 520 (3.5%) reported 562 courses of psychotropic drugs. Benzodiazepines (BDZ) accounted for the greatest number of the exposures (444/520 women); neuroleptics and an tidepressants were prescribed to tiny minorities of women (83 and 17 r espectively), mostly in those few countries were the overall prevalenc e of use of those drugs was highest. Throughout the majority of the ot her countries, overall rates were in the low range and were rather het erogeneous. With the exception of small clusters of ''unexpected'' ind ications, prescriptions of BDZ were found to be consistent with the ta rget symptoms of anxiety and insomnia; chronic use was reported in 31/ 444 women. The study was not targeted to the detection of malformation s; no suspected clustering was found, however, among the 130 women exp osed during the first trimester of pregnancy. The collaborative networ k now established provides a framework for periodically replicated sur veillance to monitor the evolution of this field of knowledge and care in order to provide reliable information for women and society.