ANTISENSE OLIGONUCLEOTIDE TO C-FOS INDUCES IPSILATERAL ROTATIONAL BEHAVIOR TO D-AMPHETAMINE

Citation
W. Sommer et al., ANTISENSE OLIGONUCLEOTIDE TO C-FOS INDUCES IPSILATERAL ROTATIONAL BEHAVIOR TO D-AMPHETAMINE, NeuroReport, 5(3), 1993, pp. 277-280
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0959-4965
Volume
5
Issue
3
Year of publication
1993
Pages
277 - 280
Database
ISI
SICI code
0959-4965(1993)5:3<277:AOTCII>2.0.ZU;2-G
Abstract
THE immediate-early genes, especially c-fos, have been suggested to ha ve an important role in neuronal plasticity and memory. However, it ha s been difficult to determine if in fact c-fos can participate in cont rol of behaviour. Here we can report that direct unilateral infusion i nto the rat neostriatum of an antisense phosphothioate oligodeoxynucle otide to c-fos mRNA leads to the rapid induction of ipsilateral rotati onal behaviour after d-amphetamine administration. This is associated with an elimination of the in vivo expression of Fos-like immunoreacti vity within the infused region of neostriatum. Following infusion of t hese oligodeoxynucleotides labelled with fluorescein isothiocyanate th ey appear with a nuclear and cytoplasmic location in a large number of nerve cells, many of which are immunoreactive for dopamine and cyclic AMP regulated phosphoprotein. The present findings suggest that the i mmediate-early gene c-fos has a role also in control of behavioural ac tivity, as illustrated in D1 receptor containing striatal neurones.