HYPOTHALAMIC NOREPINEPHRINE DEPLETION INHIBITS CRF-41 RELEASE FOLLOWING NEURAL STIMULI

Citation
S. Feldman et J. Weidenfeld, HYPOTHALAMIC NOREPINEPHRINE DEPLETION INHIBITS CRF-41 RELEASE FOLLOWING NEURAL STIMULI, NeuroReport, 5(3), 1993, pp. 258-260
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0959-4965
Volume
5
Issue
3
Year of publication
1993
Pages
258 - 260
Database
ISI
SICI code
0959-4965(1993)5:3<258:HNDICR>2.0.ZU;2-V
Abstract
THE effects of depletion of hypothalamic norepinephrine (NE) on median eminence (ME)-corticotropin-releasing factor (CRF-41) content, serum ACTH and corticosterone (CS) levels, following photic and acoustic sti mulation, were investigated. While in intact rats these stimuli caused depletion in CRF-41 and a rise in ACTH and CS level, in rats pretreat ed with 6-hydroxydopamine (6-OHDA), these effects were prevented. This would suggest that the blockage in the release of ME CRF-41 into the portal plasma following neural stimuli in rats with hypothalamic NE de pletion, is responsible for the inhibition of the pituitary-adrenocort ical response.