DIAZOXIDE SUPPRESSES SLOWLY-INACTIVATING OUTWARD AND INWARD CURRENTS IN CA1 HIPPOCAMPAL-NEURONS

Citation
G. Erdemli et K. Krnjevic, DIAZOXIDE SUPPRESSES SLOWLY-INACTIVATING OUTWARD AND INWARD CURRENTS IN CA1 HIPPOCAMPAL-NEURONS, NeuroReport, 5(3), 1993, pp. 249-251
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0959-4965
Volume
5
Issue
3
Year of publication
1993
Pages
249 - 251
Database
ISI
SICI code
0959-4965(1993)5:3<249:DSSOAI>2.0.ZU;2-I
Abstract
DIAZOXIDE (DZX) opens ATP-sensitive K (K-ATP) channels in muscle and o ther cells. In whole-cell voltage-clamp recordings in slices, in the p resence of kynurenate and bicuculline to minimize indirect effects, DZ X (0.65 mM) did not increase input conductance; but it sharply reduced persistent inward and outward currents. An inward current (peak near -20 mV) was especially clear in the presence of K channel blockers; wa s fully evident in Ca-channel blocking medium; but was abolished by te trodotoxin. The main direct effects of DZX on these neurones are thus mediated not by activation of K-ATP channels, but rather by modulation of voltage-dependent channels, including a TTX-sensitive persistent N a current and possibly a Ca current.