IONIC BASIS FOR INTRINSIC 40 HZ NEURONAL OSCILLATIONS

Authors
Citation
Xj. Wang, IONIC BASIS FOR INTRINSIC 40 HZ NEURONAL OSCILLATIONS, NeuroReport, 5(3), 1993, pp. 221-224
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0959-4965
Volume
5
Issue
3
Year of publication
1993
Pages
221 - 224
Database
ISI
SICI code
0959-4965(1993)5:3<221:IBFI4H>2.0.ZU;2-7
Abstract
WE present a biophysical model of a slowly inactivating potassium ion current I-KS based on recent voltage-clamp data from layer V pyramidal neurons in the cat sensorimotor cortex and show that the interplay be tween a persistent sodium current I-NaP and I-KS is able to produce in trinsic membrane potential oscillations in the 10- to 50-frequency ran ge. A most notable characteristic of such rhythmicity is what may be t ermed mixed-mode bursting, where clusters of action potentials alterna te in time with epochs of small subthreshold oscillations.