PHOTORESPONSIVE PACEMAKER NEURONS FROM THE DISSOCIATED RETINA OF APLYSIA

Citation
Jw. Jacklet et S. Barnes, PHOTORESPONSIVE PACEMAKER NEURONS FROM THE DISSOCIATED RETINA OF APLYSIA, NeuroReport, 5(3), 1993, pp. 209-212
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0959-4965
Volume
5
Issue
3
Year of publication
1993
Pages
209 - 212
Database
ISI
SICI code
0959-4965(1993)5:3<209:PPNFTD>2.0.ZU;2-I
Abstract
ISOLATED retinal pacemaker neurons of Aplysia devoid of any morphologi cally specialized photoreceptive processes responded to illumination. Neurons were dissociated from other retinal cells and maintained in pr imary culture for whole cell recording. The membrane potential was dep olarized and action potentials were evoked by illumination. Light adap tation diminished the response and prolonged the latency. Under voltag e clamp neurons responded with increased inward current. Responses wer e slower and smaller than specialized photoreceptor responses. Pairs a nd small clusters of monopolar neurons also responded to light. These photoresponsive monopolar neurons are likely to be the output neurons of the ocular circadian clock. Although photoresponsive central neuron s have been described in Aplysia, this is the first report of photores ponses from isolated retinal neurons.