NEOSTRIATAL GABAERGIC INTERNEURONS CONTAIN NOS, CALRETININ OR PARVALBUMIN

Citation
Y. Kubota et al., NEOSTRIATAL GABAERGIC INTERNEURONS CONTAIN NOS, CALRETININ OR PARVALBUMIN, NeuroReport, 5(3), 1993, pp. 205-208
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0959-4965
Volume
5
Issue
3
Year of publication
1993
Pages
205 - 208
Database
ISI
SICI code
0959-4965(1993)5:3<205:NGICNC>2.0.ZU;2-0
Abstract
To reveal functional heterogeneity among GABAergic interneurones in ra t neostriatum, we investigated: (1) whether nitric oxide synthase (NOS )- and calretinin-immunoreactive cells, like parvalbumin-immunoreactiv e cells, were also immunoreactive for 67 kD glutamic acid decarboxylas e (GAD(67)) and GABA; (2) whether NOS cells, calretinin cells and parv albumin cells belonged to separate populations or not. NOS cells, calr etinin cells and parvalbumin cells all showed immunoreactivity for GAD (67) in colchicine-treated rats. Calretinin cells and parvalbumin cell s were also immunoreactive for GABA. Only a few cells (0-3%) showed im munoreactivity for two antigens. These results suggest that the neostr iatum has at least three GABAergic interneuronal systems.