EFFECT OF KETAMINE ON STRESS PROTEIN IMMUNOREACTIVITIES IN RAT OLFACTORY MUCOSA

Citation
Vm. Carr et Ai. Farbman, EFFECT OF KETAMINE ON STRESS PROTEIN IMMUNOREACTIVITIES IN RAT OLFACTORY MUCOSA, NeuroReport, 5(3), 1993, pp. 197-200
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0959-4965
Volume
5
Issue
3
Year of publication
1993
Pages
197 - 200
Database
ISI
SICI code
0959-4965(1993)5:3<197:EOKOSP>2.0.ZU;2-N
Abstract
ADMINISTRATION of 9 mg ketamine per 100 g b.wt. to rats leads to trans ient enhancement of immunoreactivity to monoclonal antibodies against two stress proteins, ubiquitin and human 70 kDa heat shock protein (HS P70), in the supranuclear region of supporting cells of the olfactory epithelium and in the Bowman's gland acinar cells in the subepithelial lamina propria. In the supporting cells the enhanced immunoreactiviti es are not caused by other drugs used in our surgical anesthetic/antib iotic regimen (xylazine, buprenorphine, and gentamicin), but in Bowman 's glands they are. Results are discussed in terms of possible ketamin e binding to phencyclidine receptors (either NMDA-associated or not) a nd possible direct stress-inducing interactions of ketamine or ketamin e breakdown products with the inhalant detoxification or secretory sys tems in the reactive cells.