GROWTH-FACTORS - THERAPEUTIC ADVANCES IN WOUND-HEALING

Authors
Citation
Cj. Robinson, GROWTH-FACTORS - THERAPEUTIC ADVANCES IN WOUND-HEALING, Annals of medicine, 25(6), 1993, pp. 535-538
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
0785-3890
Volume
25
Issue
6
Year of publication
1993
Pages
535 - 538
Database
ISI
SICI code
0785-3890(1993)25:6<535:G-TAIW>2.0.ZU;2-5
Abstract
Polypeptide growth factors regulate cellular processes involved in wou nd healing. Application of exogenous growth factors can modify the hea ling process and, with recombinant DNA technology, growth factors can now be made in sufficient quantity to be used therapeutically. Several growth factors are showing promising results in clinical trials, espe cially in cases of impaired healing, such as chronic ulcers. Preclinic al studies indicate that further growth factors may have therapeutic p otential in a wide range of wound-healing applications. The use of spe cifically designed and modified growth factors, growth-factor inhibito rs, and sequential and combinatorial dosing regimes offer further poss ibilities for enhancing wound healing.