(75)SEHCAT FRACTIONAL TURNOVER RATE IN PRIMARY BILIARY-CIRRHOSIS - EFFECT OF URSODEOXYCHOLIC ACID TREATMENT

Citation
M. Fracchia et al., (75)SEHCAT FRACTIONAL TURNOVER RATE IN PRIMARY BILIARY-CIRRHOSIS - EFFECT OF URSODEOXYCHOLIC ACID TREATMENT, European journal of gastroenterology & hepatology, 5(12), 1993, pp. 1037-1041
Citations number
NO
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
ISSN journal
0954-691X
Volume
5
Issue
12
Year of publication
1993
Pages
1037 - 1041
Database
ISI
SICI code
0954-691X(1993)5:12<1037:(FTRIP>2.0.ZU;2-S
Abstract
Objective: To assess whether short-term ursodeoxycholic acid treatment in patients with primary biliary cirrhosis modifies the bile acid fra ctional turnover rate. Design: The fractional turnover rate of bite ac ids was measured according to the half-life of the orally administered gamma-emitting bile acid analogue (75)Selena homocholic acid taurine ((75)SeHCAT) in eight women with primary biliary cirrhosis before and after 4 weeks of treatment with 600 mg/day ursodeoxycholic acid. Metho ds: The half-life of (75)SeHCAT was measured according to the daily ex ponential decrease of Se-75 activity over the gall bladder area; in th e five patients who had been cholecystectomized previously, the (75)Se HCAT half-rife was measured from the exponential decrease of total abd ominal activity using the non-collimated gamma-camera. Results: Short- term ursodeoxycholic acid treatment caused a significant reduction in the (75)SeHCAT half-rife from 5.9+/-5.4 to 2.7+/-1.7 days (mean+/-SD, P<0.02), resulting in values below the normal range (2.0 days) being f ound in four out of the eight patients. Conclusion: Our results sugges t that ursodeoxycholic acid administration in primary biliary cirrhosi s increases the bile acid fractional turnover rate. Considering that u rsodeoxycholic acid has been reported not to modify the mass of all ot her bile acids in the enterohepatic circulation of such patients, we h ypothesize that th is effect is due to a combination of down-regulatio n of the ileal absorption efficiency of bile acids and increased bite acid hepatic excretion.