TULAREMIA - TREATMENT FAILURES WITH OUTPATIENT USE OF CEFTRIAXONE

Citation
Jt. Cross et Rf. Jacobs, TULAREMIA - TREATMENT FAILURES WITH OUTPATIENT USE OF CEFTRIAXONE, Clinical infectious diseases, 17(6), 1993, pp. 976-980
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology,Immunology
ISSN journal
1058-4838
Volume
17
Issue
6
Year of publication
1993
Pages
976 - 980
Database
ISI
SICI code
1058-4838(1993)17:6<976:T-TFWO>2.0.ZU;2-T
Abstract
Tularemia, an infection caused by the coccobacillus Francisella tulare nsis, can be a difficult disease process to diagnose and treat. The di fficulty in treating this disease is related to the pathophysiology of the infection and the toxicity of the antimicrobial agents presently recommended for treatment. Recent in vitro data have suggested that an timicrobial drugs other than standard agents (streptomycin, gentamicin , chloramphenicol, or tetracycline) may be effective. We present eight cases of documented failure of outpatient use of ceftriaxone in the t reatment of tularemia. Our data suggest that while ceftriaxone may hav e excellent MICs in vitro, these MICs do not necessarily correlate wit h successful in vivo outcomes.