INFLUENCE OF HUMATE ON CALCIUM HYDROXYAPATITE IMPLANTS

Authors
SCHLICKEWEI W RIEDE UN YU J ZIECHMANN W KUNER EH SEUBERT B
Citation
W. Schlickewei et al., INFLUENCE OF HUMATE ON CALCIUM HYDROXYAPATITE IMPLANTS, Archives of orthopaedic and trauma surgery, 112(6), 1993, pp. 275-279
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Orthopedics,Surgery
Journal title
Archives of orthopaedic and trauma surgery → ACNP
ISSN journal
0936-8051
Volume
112
Issue
6
Year of publication
1993
Pages
275 - 279
Database
ISI
SICI code
0936-8051(1993)112:6<275:IOHOCH>2.0.ZU;2-#
Abstract
Implanted bovine apatite is highly osteoconductive, since it serves th e host tissue as a ''guide-line'' for the deposition of newly developi ng bone tissue. It is well tolerated, but it showed no signs of being resorbed during the course of the experiment. Previous impregnation of the bovine hydroxyapatite with a low molecular humate substance obvio usly encourages its resorption. This is most easily explained by the k nown ability of humate to induce the activation of leucocytes. The occ asional over-resorption of the apatite is dependent (1) upon the prepa ration of the implant (granulate) and (2) the local concentration of t he humate. Future research is being directed towards the production of a satisfactorily usable form of humate and apatite and the investigat ion of its HIV blocking action on heterologous cancellous bone.