SOUTHWESTERN INTERNAL-MEDICINE CONFERENCE - NITRIC-OXIDE

Authors
Citation
Ra. Star, SOUTHWESTERN INTERNAL-MEDICINE CONFERENCE - NITRIC-OXIDE, The American journal of the medical sciences, 306(5), 1993, pp. 348-358
Citations number
110
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
ISSN journal
0002-9629
Volume
306
Issue
5
Year of publication
1993
Pages
348 - 358
Database
ISI
SICI code
0002-9629(1993)306:5<348:SIC-N>2.0.ZU;2-7
Abstract
Nitric oxide is a newly discovered gas that mediates communication bet ween adjacent cells and signals inside cells. Defects in the nitric ox ide signalling cascade have been found in patients with systemic hyper tension, pulmonary hypertension, and coronary artery disease. High con centrations of nitric oxide are cytotoxic. Over-production of nitric o xide contributes to the pathogenesis of septic shock and uremic bleedi ng. This review focuses on the cardiovascular and platelet actions of nitric oxide, with emphasis on clinical studies of agents that modulat e the nitric oxide signalling cascade.