HEMOSTATIC MOLECULAR MARKERS IN NEPHROTIC SYNDROME

Citation
Ty. Chen et al., HEMOSTATIC MOLECULAR MARKERS IN NEPHROTIC SYNDROME, American journal of hematology, 44(4), 1993, pp. 276-279
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
ISSN journal
0361-8609
Volume
44
Issue
4
Year of publication
1993
Pages
276 - 279
Database
ISI
SICI code
0361-8609(1993)44:4<276:HMMINS>2.0.ZU;2-H
Abstract
Quantitative changes of hemostatic molecular markers were studied in p atients with nephrotic syndrome. The plasma levels of fibrinopeptide A (FPA), thrombin-antithrombin III complex (TAT), products of thrombin activation, and fragment F1 + 2 (F1 + 2), a product of prothrombin act ivation, were measured by enzyme immunoassay in 21 patients with nephr otic syndrome and in 16 normal controls. The mean value of FPA was 17. 5 +/- 7.5 ng/ml(mean +/- SD) in nephrotic patients and 4.5 +/- 0.3 ng/ ml in normal controls (P < 0.02); F1 + 2 concentration was 1.4 +/- 0.3 ng/ml in nephrotic patients and 0.5 +/- 0.1 ng/ml in normal controls (P < 0.001); TAT level was 1.0 +/- 0.3 mu g/l in nephrotic patients an d 0.2 +/- 0.1 mu g/l in normal controls (P < 0.05). These data indicat ed intravascular hemostasis activation. Based on these results, we pro pose that low antithrombin III level in nephrotic patients may be due to both urinary loss and intravascular consumption. (C) 1993 Wiley-Lis s, Inc.