SUPPRESSION BY KAMPO MEDICINES IN PRENEOPLASTIC MAMMARY HYPERPLASTIC ALVEOLAR NODULES OF SHN VIRGIN MICE

Citation
S. Sakamoto et al., SUPPRESSION BY KAMPO MEDICINES IN PRENEOPLASTIC MAMMARY HYPERPLASTIC ALVEOLAR NODULES OF SHN VIRGIN MICE, Planta medica, 59(5), 1993, pp. 425-427
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
ISSN journal
0032-0943
Volume
59
Issue
5
Year of publication
1993
Pages
425 - 427
Database
ISI
SICI code
0032-0943(1993)59:5<425:SBKMIP>2.0.ZU;2-Z
Abstract
Sho-saiko-to (SST), Keishi-bukuryo-gan (KBG), and Shakuyaku-kanzo-to ( SKT) are Japanese modified traditional Chinese herbal medicines (Kampo medicines) consisting of 7, 5, and 2 medical plants, respectively. It is known that the hyperplastic alveolar nodule (HAN) is a representat ive preneoplastic state in the mammary glands of mice. We examined the effects of SST, KBG, and SKT on the formation and growth of HAN in a high-mammary-tumor strain of SHN virgin mice. Oral administration of S ST for 60 days beginning at 90 days of age reduced the number and area of HAN and mammary thymidylate synthetase activity with a reduction o f serum prolactin level. There was little difference between the other experimental groups and the control in the formation and growth of HA N and the enzyme activities. These results indicate that SST may have a preventive effect on malignant mammary transformations.