ALCOHOL-CONSUMPTION AND RISK OF PANCREATIC-CANCER

Citation
A. Tavani et al., ALCOHOL-CONSUMPTION AND RISK OF PANCREATIC-CANCER, Nutrition and cancer, 27(2), 1997, pp. 157-161
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Nutrition & Dietetics",Oncology
Journal title
ISSN journal
0163-5581
Volume
27
Issue
2
Year of publication
1997
Pages
157 - 161
Database
ISI
SICI code
0163-5581(1997)27:2<157:AAROP>2.0.ZU;2-H
Abstract
The relation between pancreatic cancer and alcohol consumption was inv estigated in a case-control study conducted in Milan, Northern Italy, between 1983 and 1992 On 361 incident histologically confirmed cases a nd 997 controls admitted to hospital for acute nonneoplastic diseases apparently unrelated to alcohol and tobacco consumption. Compared with teetotalers, the multivariate odds ratio (OR) of pancreatic cancer, a fter adjustment for age, sex, education, smoking status, and history o f diabetes, pancreatitis, and cholelithiasis, were 0.9 for alcohol dri nkers and 0.9, 1.1, 1.4, and 1.1 for those who consumed up to four, mo re than four to seven, more than seven to eight, or more than eight al coholic drinks per day; none of the estimates or the trend in risk was significant. OR were also close to unity in the separate analysis of wine, beer, and spirit intake, with no trend in risk, and no relations hip was observed for duration of use (OR = 0.7 for >40 yrs of use). No interaction was observed between pancreatic cancer and total alcohol intake in separate strata of age, sex, education, and smoking status. Thus the findings of the present study, on the basis of a population w ith relatively frequent and high alcohol consumption, provide epidemio logic evidence that even high alcohol intake does not appreciably modi fy the risk of pancreatic cancer.