INFLUENCE OF CGS-8216 ON SOME ACUTE EFFECTS OF ETHANOL

Citation
J. Kotlinska et R. Langwinski, INFLUENCE OF CGS-8216 ON SOME ACUTE EFFECTS OF ETHANOL, Alcohol and alcoholism, 30(5), 1995, pp. 601-605
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
30
Issue
5
Year of publication
1995
Pages
601 - 605
Database
ISI
SICI code
0735-0414(1995)30:5<601:IOCOSA>2.0.ZU;2-6
Abstract
The central pharmacological effects of ethanol are well known and rese mble those of the benzodiazepines (BZD). In addition BZD may interact with ethanol, resulting in enhanced cerebral depression. Ro 15-4513, B ZD inverse agonist, potentially antagonizes a lot of effects of ethano l but not all. In our study, another BZD inverse agonist, CGS 8216, re verses the hypnotic effect of ethanol and hypoactivity in mice and rat s. CGS 8216 increased also ethanol's locomotor stimulation in mice. Th is supports the hypothesis that some effects of ethanol are mediated b y the GABA-BZD-chloride channel receptor complex. Our behavioural expe riments described in this report suggest that CGS 8216, like Ro 15-451 3, may act on the alpha-6 subunit of this receptor complex.