ADDITIONAL BIOACTIVE ACETOGENINS, ANNOMUTACIN AND (2,4-TRANS)-10R-ANNONACIN-A-ONES AND (2,4-CIS)-10R-ANNONACIN-A-ONES, FROM THE LEAVES OF ANNONA-MURICATA

Citation
Fe. Wu et al., ADDITIONAL BIOACTIVE ACETOGENINS, ANNOMUTACIN AND (2,4-TRANS)-10R-ANNONACIN-A-ONES AND (2,4-CIS)-10R-ANNONACIN-A-ONES, FROM THE LEAVES OF ANNONA-MURICATA, Journal of natural products, 58(9), 1995, pp. 1430-1437
Citations number
32
Language
INGLESE
art.tipo
Note
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
ISSN journal
0163-3864
Volume
58
Issue
9
Year of publication
1995
Pages
1430 - 1437
Database
ISI
SICI code
0163-3864(1995)58:9<1430:ABAAA(>2.0.ZU;2-C
Abstract
In a continuation of our research on bioactive components from the lea ves of Annona muricata, three novel monotetrahydrofuran Annonaceous ac etogenins, namely, annomutacin [1], (2,4-trans)-10R-annonacin-A-one [2 ], and (2,4-cis)-10R-annonacin-A-one [3], have been identified. Their structures were deduced by ms, nmr, ir, and uv spectral and chemical m ethods, and the absolute configurations were determined by Mosher este r methodology. A known bioactive amide, N-p-coumaroyl tyramine, was al so found. Compound 1 and the mixture of compounds 2 and 3 showed selec tive cytotoxicities against the human A-549 lung tumor cell line.