IDENTIFICATION OF AN N-ACETYL KETO DERIVATIVE OF FUMONISIN B-1 IN CORN CULTURES OF FUSARIUM-PROLIFERATUM

Citation
Sm. Musser et al., IDENTIFICATION OF AN N-ACETYL KETO DERIVATIVE OF FUMONISIN B-1 IN CORN CULTURES OF FUSARIUM-PROLIFERATUM, Journal of natural products, 58(9), 1995, pp. 1392-1397
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
ISSN journal
0163-3864
Volume
58
Issue
9
Year of publication
1995
Pages
1392 - 1397
Database
ISI
SICI code
0163-3864(1995)58:9<1392:IOANKD>2.0.ZU;2-3
Abstract
A method is presented for the separation and identification of a new N -acetyl keto derivative of fumonisin B-1 (FB1) produced in solid corn culture. Cultures of Fusarium proliferatum (M-1597) were purified usin g preparative hplc, and the new fumonisin was detected by negative-ion esms. Structures were confirmed by H-1- and C-13-nmr spectroscopy. Th e new fumonisin differs from FB1 in that the tricarballylic acid funct ionality at the C-15 position of the eicosane backbone is replaced by a ketone and the amino group is acetylated. Direct analysis of the cul ture material by negative-ion electrospray lc/ms confirmed that the ne w fumonisin is produced naturally by the fungus.