ENZYME-INHIBITORS - NEW AND KNOWN POLYBROMINATED PHENOLS AND DIPHENYLETHERS FROM 4 INDO-PACIFIC DYSIDEA SPONGES

Citation
Xo. Fu et al., ENZYME-INHIBITORS - NEW AND KNOWN POLYBROMINATED PHENOLS AND DIPHENYLETHERS FROM 4 INDO-PACIFIC DYSIDEA SPONGES, Journal of natural products, 58(9), 1995, pp. 1384-1391
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
ISSN journal
0163-3864
Volume
58
Issue
9
Year of publication
1995
Pages
1384 - 1391
Database
ISI
SICI code
0163-3864(1995)58:9<1384:E-NAKP>2.0.ZU;2-#
Abstract
Extracts and pure compounds isolated from four samples of Dysidea sp. sponges collected from two geographically distinct regions of the Indo -Pacific (Chuuk Atoll and Fiji) mere assayed against five different en zyme assays, four of which are relevant to anticancer drug discovery a nd one of which (15-lipoxygenase) may detect compounds significant in modulating the development of atherosclerotic plaque. The pure compoun ds that inhibited various enzymes were polybrominated phenols and poly brominated phenoxyphenols. Fourteen of these phenols were isolated, si x of which were new compounds. A variety of the phenols inhibited inos ine monophosphate dehydrogenase (IMPDH), guanosine monophosphate synth etase, and 15-lipoxygenase. No activity was observed with protein tyro sine kinase pp60(v-src) or matrix metalloprotease.