INCREASED RISK OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS AT LOW PLASMA VITAMIN-E CONCENTRATIONS - A 4 YEAR FOLLOW-UP-STUDY IN MEN

Citation
Jt. Salonen et al., INCREASED RISK OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS AT LOW PLASMA VITAMIN-E CONCENTRATIONS - A 4 YEAR FOLLOW-UP-STUDY IN MEN, BMJ. British medical journal, 311(7013), 1995, pp. 1124-1127
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
ISSN journal
0959-8138
Volume
311
Issue
7013
Year of publication
1995
Pages
1124 - 1127
Database
ISI
SICI code
0959-8138(1995)311:7013<1124:IRONDA>2.0.ZU;2-A
Abstract
Objective-To investigate whether low vitamin E status is a risk factor for incident non-insulin dependent diabetes mellitus. Design-Populati on based follow up study with diabetes assessed at baseline and at fou r years. Setting-Eastern Finland. Subjects-Random sample of 944 men ag ed 42-60 who had no diabetes at the baseline examination. Intervention -Oral glucose tolerance test at four year follow up. Main outcome meas ures-A man was defined diabetic if he had either (a) a fasting blood g lucose concentration greater than or equal to 6.7 mmol/l, or (b) a blo od glucose concentration greater than or equal to 10.0 mmol/l two hour s after a glucose load, or (c) a clinical diagnosis of diabetes with e ither dietary, oral, or insulin treatment. Results-45 men developed di abetes during the follow up period. In a multivariate logistic regress ion model including the strongest predictors of diabetes, a low lipid standardised plasma vitamin E (below median) concentration was associa ted with a 3.9-fold (95% confidence interval 1.8-fold to 8.6-fold) ris k of incident diabetes. A decrement of 1 mu mol/l of uncategorised uns tandardised vitamin E concentration was associated with an increment o f 22% in the risk of diabetes when allowing for the strongest other ri sk factors as well as serum low density lipoprotein cholesterol and tr iglyceride concentrations. Conclusions-There was a strong independent association between low vitamin E status before follow up and an exces s risk of diabetes at four years. This supports the theory that free r adical stress has a role in the causation of non-insulin dependent dia betes mellitus.