ATTRIBUTABLE RISKS FOR BREAST-CANCER IN ITALY - EDUCATION, FAMILY HISTORY AND REPRODUCTIVE AND HORMONAL FACTORS

Citation
A. Tavani et al., ATTRIBUTABLE RISKS FOR BREAST-CANCER IN ITALY - EDUCATION, FAMILY HISTORY AND REPRODUCTIVE AND HORMONAL FACTORS, International journal of cancer, 70(2), 1997, pp. 159-163
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
ISSN journal
0020-7136
Volume
70
Issue
2
Year of publication
1997
Pages
159 - 163
Database
ISI
SICI code
0020-7136(1997)70:2<159:ARFBII>2.0.ZU;2-5
Abstract
The percent population attributable risk (AR) for breast cancer was es timated in relation to education, family history of the disease and so me reproductive and hormonal factors, using data from a case control s tudy conducted between lune 1991 and February 1994 in 6 Italian centre s on 2,569 histologically confirmed incident breast cancer cases and 2 ,588 controls, admitted to hospital for a wide range of acute, nonneop lastic, non-hormone-related diseases. On the basis of multivariate odd s ratios, a high level of education accounted for 20% of cases, elevat ed age at first birth and nulliparity for 38% and a family history of breast cancer in first degree relatives for 7%. Education and nullipar ity and age at first birth together explained 47% of all breast cancer cases, and the combination of these 2 factors plus a family history o f the disease explained 50% of cases. In pre-menopausal women a high l evel of education accounted for 31% of all breast cancer cases, older age at first birth for 44% and the combination of the 2 factors for 49 %. In post-menopausal women the corresponding values were 13%, 31% and 42%; further addition of risk associated with family history of the d isease explained 52% of pre-menopausal cases. In post-menopausal women older age at menopause and the use of hormone replacement therapy acc ounted for 15% and 2% of breast cancer cases, respectively. The combin ation of risks associated with a high level of education, old age at f irst birth and nulliparity and older age at menopause accounted for 51 % of cases; further inclusion of risk associated with use of hormone r eplacement therapy explained 52%, and the AR resulting from these 4 ri sk factors combined plus a family history of breast cancer was 56%. Th us, a few selected and well-identified risk factors explain about one- half the breast cancer cases in this Italian population. (C) 1997 Wile y-Liss, Inc.