OSTEOCALCIN METABOLISM IN LATE FETAL LIFE - FETAL AND MATERNAL OSTEOCALCIN LEVELS

Citation
O. Alatas et al., OSTEOCALCIN METABOLISM IN LATE FETAL LIFE - FETAL AND MATERNAL OSTEOCALCIN LEVELS, Clinica chimica acta, 239(2), 1995, pp. 179-183
Citations number
8
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Medicinal",Biology
Journal title
ISSN journal
0009-8981
Volume
239
Issue
2
Year of publication
1995
Pages
179 - 183
Database
ISI
SICI code
0009-8981(1995)239:2<179:OMILFL>2.0.ZU;2-#
Abstract
To clarify the osteocalcin metabolism in the fetus, we determined veno us osteocalcin levels of 13 women and umbilical arterial and venous os teocalcin levels of their newborns at delivery. Calcium, phosphorus an d alkaline phosphatase levels were also established. Umbilical arteria l and venous blood calcium and phosphorus levels were significantly hi gher than maternal venous blood values (P < 0.001 for all). Umbilical arterial calcium was 2.46 +/- 0.02 mmol/l, phosphorus 1.48 +/- 0.04 mm ol/l, umbilical venous calcium 2.50 +/- 0.03 mmol/l, phosphorus 1.45 /- 0.04 mmol/l, maternal calcium 2.16 +/- 0.03 mmol/l, phosphorus 0.98 +/- 0.04 mmol/l. Both umbilical venous (5.85 +/- 0.66 nmol/l) and art erial (3.49 +/- 0.51 nmol/l) osteocalcin levels were significantly hig her than maternal values (1.42 +/- 0.15 nmol/l). The high umbilical ve nous osteocalcin levels may be due to increased osteocalcin degradatio n in fetus or placental osteocalcin synthesis.