DETERMINATION OF TOTAL ARSENIC IN SERUM AND PACKED CELLS OF PATIENTS WITH RENAL-INSUFFICIENCY

Citation
X. Zhang et al., DETERMINATION OF TOTAL ARSENIC IN SERUM AND PACKED CELLS OF PATIENTS WITH RENAL-INSUFFICIENCY, Fresenius' journal of analytical chemistry, 353(2), 1995, pp. 143-147
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Analytical
ISSN journal
0937-0633
Volume
353
Issue
2
Year of publication
1995
Pages
143 - 147
Database
ISI
SICI code
0937-0633(1995)353:2<143:DOTAIS>2.0.ZU;2-G
Abstract
In order to investigate the arsenic level in serum and packed cells of patients with renal insufficiency, total arsenic (As) concentrations were determined with hydride generation atomic absorption spectrometry (HGAAS) in serum (S) and packed cells (PC) of 31 non-dialyzed patient s. The accuracy of the method was tested by the analysis of arsenic in 3 certified reference materials. Patients showed a three-fold increas e of arsenic concentrations in serum and a two-fold increase of arseni c in packed cells compared with controls. Patients (n = 10) with highe r serum creatinine (> 2.0 mg/dL), urea (>0.70 g/L) and urinary protein (mean +/- SD: 1.12 +/- 0.8 2 g/L) showed higher arsenic concentration s (5.8 +/- 3.3 mu g/L in serum and 18.0 +/- 16.7 mu g/kg in packed cel ls) compared with those with lower creatinine (< 1.6 mg/dL), urea (< 0 .6 g/L) and urinary protein (mean +/- SD: 0.27 +/- 10.82 g/L) (n = 16, serum arsenic 1.2 +/- 1.2 mu g/L, packed cells arsenic 2.6 +/- 1.9 mu g/kg). The significant differences (both p < 0.001) in S and PC-arsen ic levels of patients in group I and II implies a relationship between the arsenic level and the degree of chronic renal insufficiency.