THE EFFECTS OF THE SEROTONIN(1A) RECEPTOR AGONIST BUSPIRONE ON TOLBUTAMIDE-INDUCED HYPOGLYCEMIA IN RATS

Citation
Y. Sugimoto et al., THE EFFECTS OF THE SEROTONIN(1A) RECEPTOR AGONIST BUSPIRONE ON TOLBUTAMIDE-INDUCED HYPOGLYCEMIA IN RATS, Biological & pharmaceutical bulletin, 18(9), 1995, pp. 1296-1298
Citations number
11
Language
INGLESE
art.tipo
Note
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
0918-6158
Volume
18
Issue
9
Year of publication
1995
Pages
1296 - 1298
Database
ISI
SICI code
0918-6158(1995)18:9<1296:TEOTSR>2.0.ZU;2-O
Abstract
The effects of the serotonin(1A)(5-HT1A) receptor agonist buspirone on hypoglycemia elicited by tolbutamide were investigated in rats. Buspi rone, at doses not affecting plasma glucose levels, inhibited the hypo glycemic effects of tolbutamide. The inhibitory effects of buspirone o n tolbutamide-induced hypoglycemia were antagonized by the 5-HT1A rece ptor antagonist pindolol. As tolbutamide is known to induce hypoglycem ia by facilitating insulin release, the effects of buspirone on a tolb utamide-induced increase in serum insulin levels were also studied. Ho wever, buspirone did not affect tolbutamide-induced insulin release. A drenodemedullation inhibited the effects of buspirone. These results s uggest that buspirone inhibits tolbutamide-induced hypoglycemia mediat ed by the 5-HT1A receptor, and adrenaline release may be involved in t he effects of buspirone.