SERUM INSULIN-LIKE GROWTH-FACTORS (IGFS) AND IGF BINDING-PROTEIN-1, BINDING-PROTEIN-2, AND BINDING-PROTEIN-3 IN CHILDREN WITH CHRONIC-RENAL-FAILURE - RELATIONSHIP TO HEIGHT AND GLOMERULAR-FILTRATION RATE

Citation
B. Tonshoff et al., SERUM INSULIN-LIKE GROWTH-FACTORS (IGFS) AND IGF BINDING-PROTEIN-1, BINDING-PROTEIN-2, AND BINDING-PROTEIN-3 IN CHILDREN WITH CHRONIC-RENAL-FAILURE - RELATIONSHIP TO HEIGHT AND GLOMERULAR-FILTRATION RATE, The Journal of clinical endocrinology and metabolism, 80(9), 1995, pp. 2684-2691
Citations number
51
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrynology & Metabolism
ISSN journal
0021-972X
Volume
80
Issue
9
Year of publication
1995
Pages
2684 - 2691
Database
ISI
SICI code
0021-972X(1995)80:9<2684:SIG(AI>2.0.ZU;2-H
Abstract
Serum levels of insulin-like growth factor I(IGF-I), IGF-II, and IGF b inding protein 1 (IGFBP-1), IGFBP-2, and IGFBP-3 were measured in 94 c hildren with chronic renal failure (CRF). The results were compared wi th their respective age-dependent normal ranges, and the relationship with height and residual glomerular filtration rate (GFR) was examined . Each IGF and IGFBP was quantified by specific RIA. Serum IGF-I and I GF-IT levels were in the normal range throughout their entire childhoo d in the vast majority of cases. The mean age-related IGF-I (0.07 +/- 0.14 SD score) and IGF-II levels (0.06 +/- 0.11 SD) were similar. Age- related IGF-II but not IGF-I levels showed a weak: inverse linear corr elation with residual GFRs (r = -0.24, P < 0.02). Mean age-related IGF BP-1 serum levels (1.04 +/- 0.09 SD) were slightly elevated, whereas m ean age-related serum IGFBP-2 levels (3.25 +/- 0.20 SD) and serum IGFB P-3 levels (2.61 +/- 0.12 SD) were markedly elevated. Significant inve rse correlations were found between GFRs and age-related IGFBP-1 (r = -0.42, P < 0.001), IGFBP-2 (r = -0.56, P < 0.001), and IGFBP-3 (r = -0 .28, P < 0.005), but the increase in IGFBP-2 with declining GFR was re latively more pronounced than the respective increase in IGFBP-1 and I GFBP-3. The correlation between age-related IGF-I and relative height in prepubertal children with CRF (n = 54, r = 0.43,P < 0.001) was lowe r than in prepubertal controls (n = 68, r = 0.67, P < 0.001), and the slope of the regression line was significantly less steep, indicating that the normal relationship between IGF-I and height is disturbed in CRF. The normal relationship between IGFBP-3 and height was disrupted in CRF. Forward stepwise regression analysis revealed that height in C RF is correlated with IGF-I and inversely correlated with IGFBP-2. We conclude that the imbalance between normal IGFs and excessive IGFBP se rum levels in CRF plays a pathogenic role in the growth failure of the se children.