EXPERIMENTAL COLITIS ALTERS MYENTERIC NERVE FUNCTION AT INFLAMED AND NONINFLAMED SITES IN THE RAT

Citation
K. Jacobson et al., EXPERIMENTAL COLITIS ALTERS MYENTERIC NERVE FUNCTION AT INFLAMED AND NONINFLAMED SITES IN THE RAT, Gastroenterology, 109(3), 1995, pp. 718-722
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
ISSN journal
0016-5085
Volume
109
Issue
3
Year of publication
1995
Pages
718 - 722
Database
ISI
SICI code
0016-5085(1995)109:3<718:ECAMNF>2.0.ZU;2-K
Abstract
Background and Aims: Studies in inflammatory bowel disease have shown extensive structural abnormalities in the enteric nervous system of in flamed and noninflamed gut; however, functional correlates are lacking . The aim of this study was to determine the effect of colitis on myen teric nerve functional inflamed and noninflamed sites in rat intestine . Methods: Tritiated noradrenaline release was measured from longitudi nal muscle myenteric plexus preparations from the distal and transvers e colon and terminal ileum of rats with colitis induced by trinitroben zene sulfonic acid or Trichinella spiralis larvae. Results: As charact erized by myeloperoxidase activity and histology, both models induced inflammation restricted to the distal colon. In the distal colon in tr initrobenzene sulfonic acid colitis, KCl- or electrical field stimulat ion-evoked H-3 release was suppressed by 56% and 60%, respectively; in T. spiralis-infected rats, the KCl-evoked release was sup pressed by 58%. H-3 release was also suppressed by similar magnitudes in noninfla med transverse colon and terminal ileum of each model. Conclusions: Ex perimental distal colitis alters myenteric nerve function in inflamed distal colon and noninflamed gut regions. These changes are independen t of the manner in which colitis is induced and provide a basis for th e extensive disruption of physiological function observed in inflammat ory bowel disease.