R. Gupta et al., CORRELATION OF LIPOPROTEIN (A) TO ANGIOGRAPHICALLY DEFINED CORONARY-ARTERY DISEASE IN INDIANS, International journal of cardiology, 57(3), 1996, pp. 265-270
Lipoprotein (a) [Lp(a)] levels have been correlated with angiographica
lly defined coronary artery disease (CAD). Pattern of Lp(a) distributi
on in various racial groups is different. To study this relationship i
n Indian patients, plasma levels of Lp(a) and other lipid values were
assessed in 101 patients undergoing coronary arteriography. Lp(a) conc
entration was higher in CAD group (n=77) compared to normal coronary a
rtery group (n=24) (26.83+/-22.09 mg/dl vs. 15.07+/-14.61 mg/dl, P <0.
05). Lp(a) values had graded association with CAD. In Lp(a) quartile o
f <5 mg/dl, 66.7%. patients had CAD; in Lp(a) quartile of 5-25 mg/dl,
69.0% had CAD; in Lp(a) quartile of 26-75 mg/dl, 87.5% had CAD; and in
Lp(a) quartile of greater than or equal to 6 mg/dl, all patients had
CAD. High density lipoprotein (HDL) cholesterol was higher in the norm
al coronary artery group as compared to CAD group (45.25+/-8.26 mg/dl
vs. 41.83+/-16.47 mg/dl; NS). In HDL quartile of <35 mg/dl, 88.9% pati
ents had angiographically defined CAD. plasma values of total choleste
rol, triglycerides (TG), apolipoprotein-Al (Ape-Al), apolipoprotein-B
(Apo-B), low density lipoprotein (LDL) cholesterol, LDL/HDL cholestero
l ratio and Apo Al/B ratio were not significantly different in the gro
ups with normal coronary arteries and CAD. Our results indicate that t
he measurement of Lp(a) provides a better marker for predicting the pr
esence of angiographically defined CAD as compared to traditional meas
ures.