A. Lucas et al., FINE-NEEDLE ASPIRATION CYTOLOGY OF BENIGN NODULAR THYROID-DISEASE - VALUE OF RE-ASPIRATION, European journal of endocrinology, 132(6), 1995, pp. 677-680
Fine-needle aspiration cytology (FNAC) has become a widespread procedu
re for the study of thyroid nodules (TN), Some authors recommend the p
ractice of repeated punctures for their follow-up. This study was done
to determine the usefulness of repeated FNAC in patients with benign
nodular thyroid disease. We have studied 251 fine-needle re-aspiration
s performed on 116 females aged 45.6+/-14 years with benign nodular th
yroid disease. The time elapsed between each consecutive FNAC was 1 ye
ar, No patients presented any changes in the size or consistency of th
eir nodular goiters during this period; all FNACs were carried out by
the same physician in the same thyroid area according to the Lowhagen
technique, with a minimum of two or three aspirations of each nodule,
and processed in the same way and valued by the same cytologist withou
t any knowledge of previous cytological diagnoses. These were done usi
ng strictly classical criteria (Lowhagen), One hundred and five out of
116 patients (90.51%) with two consecutive FNACs (210) showed identic
al cytological diagnoses in the two specimens studied. The remaining 1
1 patients (9.48%) with two FNACs were diagnosed with colloid goiter a
nd cyst alternately, Fifteen out of 19 patients (78.94%) with three FN
ACs showed identical cytological diagnoses in the three samples and th
e rest (21%) also demonstrated alternate diagnoses of colloid goiter a
nd cyst, Our results show that the routine performance of repeated FNA
C in the followup of females with benign nodular thyroid disease, with
out any clinical changes, is of limited usefulness.