MAGNETIC-RESONANCE-IMAGING IN ALCOHOLIC KORSAKOFFS-SYNDROME - EVIDENCE FOR AN ASSOCIATION WITH ALCOHOLIC DEMENTIA

Citation
R. Emsley et al., MAGNETIC-RESONANCE-IMAGING IN ALCOHOLIC KORSAKOFFS-SYNDROME - EVIDENCE FOR AN ASSOCIATION WITH ALCOHOLIC DEMENTIA, Alcohol and alcoholism, 31(5), 1996, pp. 479-486
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
31
Issue
5
Year of publication
1996
Pages
479 - 486
Database
ISI
SICI code
0735-0414(1996)31:5<479:MIAK-E>2.0.ZU;2-K
Abstract
A magnetic resonance imaging study of 19 alcoholic Korsakoff patients, 17 non-amnesic alcoholics and 23 non-alcoholic controls was undertake n. Several measures of ventricular size and interhemispheric area were significantly greater in the Korsakoff patients. Interhemispheric fis sure size was greater in the non-amnesic alcoholics than the non-alcoh olic controls. Cortical grey matter T-1 values were essentially the sa me for the three groups, whereas the deep grey and the white matter T- 1 values for the Korsakoff patients were significantly greater than th e non-alcoholic controls. These results indicate widespread cerebral a trophy in alcoholic Korsakoff patients, which is largely subcortical a nd does not develop independently of the diencephalic pathology. Alcoh olic dementia may be a more severe form of alcoholic Korsakoff syndrom e, aetiologically related to the nutritionally-induced diencephalic pa thology, rather than the neurotoxic effects of alcohol on the cortex.