UTILITY OF ALBUSURE TEST IN SCREENING FOR EARLY-STAGE OF DIABETIC NEPHROPATHY

Citation
Z. Jin et al., UTILITY OF ALBUSURE TEST IN SCREENING FOR EARLY-STAGE OF DIABETIC NEPHROPATHY, Chinese medical journal, 107(9), 1994, pp. 699-702
Citations number
6
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
0366-6999
Volume
107
Issue
9
Year of publication
1994
Pages
699 - 702
Database
ISI
SICI code
0366-6999(1994)107:9<699:UOATIS>2.0.ZU;2-C
Abstract
All diabetic patients should be screened for the early stage of diabet ic nephropathy, because microalbuminuria has a great prognostic signif icance, The albusure test (AT), alatex agglutination nephelometric imm unoassay, is a rapid and low cost test for the detection of microalbum inuria of 30mg/L or more, We compared the results of AT and of radioim munoassay (RIA) for urinary albumin to evaluate the clinical utility o f AT using fresh urine samples from 74 diabetic patients without persi stent proteinuria and from 11 healthy subjects. Urinary albumin levels measured by RIA were 6.0+/-2.3mg/L in the healthy subjects, 11.0+/-8. 7mg/L in the AT-negative group (n=61), and 38.1+/-10.2mg/L in the AT-p ositive group (n=13). Using a cut-off value of 30mg/L by RIA, the rate of coincidence between AT and RIA was 89.2%, although five subjects w ere false-positive by AT, and three were false-negative, These results show that AT may provide a useful monitor microalbuminuria, a reliabl e early mark of diabetic nephropathy.