AN EXPERIMENTAL TRIAL OF ARTEMETHER IN TREATMENT OF PNEUMOCYSTIS-CARINII IN IMMUNOSUPPRESSED RATS

Citation
Yt. Chen et al., AN EXPERIMENTAL TRIAL OF ARTEMETHER IN TREATMENT OF PNEUMOCYSTIS-CARINII IN IMMUNOSUPPRESSED RATS, Chinese medical journal, 107(9), 1994, pp. 673-677
Citations number
3
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
0366-6999
Volume
107
Issue
9
Year of publication
1994
Pages
673 - 677
Database
ISI
SICI code
0366-6999(1994)107:9<673:AETOAI>2.0.ZU;2-Y
Abstract
An immunosuppressed rat model was established by injecting cortisone a cetate 25 mg/rat twice a week for 4 weeks and 12.5 mg/rat for another 2 weeks subcutaneously. A development of Pneumocystis carinii pneumoni a (PCP) was found at the end of the 6th week in all rats, These rats w ere injected intramuscularly with artemether at 100 mg/kg once a day f or 5 consecutive days, Ail rats were necropsied at the end of the 8th week, The lung impression smears were stained with Gomori's stain, and Pneumocystis carinii cysts were counted, The ultrastructural changes of trophozoite, precyst and cyst were investigated by transmission ele ctron microscopy on the 7th day after treatment.