LOW-DOSE CYCLOSPORINE-A AND TRIPTERYGIUM-WOLFORDII INHIBITED PORCINE INTESTINAL ALLOGRAFT-REJECTION

Authors
Citation
Cx. Liao et Js. Li, LOW-DOSE CYCLOSPORINE-A AND TRIPTERYGIUM-WOLFORDII INHIBITED PORCINE INTESTINAL ALLOGRAFT-REJECTION, Chinese medical journal, 107(9), 1994, pp. 669-672
Citations number
8
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
0366-6999
Volume
107
Issue
9
Year of publication
1994
Pages
669 - 672
Database
ISI
SICI code
0366-6999(1994)107:9<669:LCATIP>2.0.ZU;2-1
Abstract
The aim of this study was to evaluate whether Tripterygium wolfordii ( TW) could be used as an immunosuppressant, and whether antirejection t herapy with low-dose cyclosporin A (CsA) and TW was better than the tr eatment with large-dose CsA alone in intestinal transplantation in pig s, 100 cm intestines were transplanted by using two-step models, Four pigs which received large-dose CsA for 100 days and then were given TW survived 251.5+/- 181.5 days; 2 of these died of pneumonia 92 and 97 days after the operations respectively. Five pigs which received low-d ose CsA and TW for 100 days, then TW was the only drug used in the sur vival animals, survived 243.2+/-90.9 days; none of these succumbed to infection, All the grafts in those which were administered with low-do se CsA were destroyed by acute rejection at 12.4+/-2.6 days, These res ults indicated that TW had some immunosuppressive effects, and antirej ection treatment with low-dose CsA and TW could be considered as an ac ceptable therapy in small bowel transplantation.