ESTROGEN AND PROGESTERONE RECEPTORS IN NORMAL CERVIX AND PRIMARY CERVICAL-CARCINOMA

Citation
S. Keng et al., ESTROGEN AND PROGESTERONE RECEPTORS IN NORMAL CERVIX AND PRIMARY CERVICAL-CARCINOMA, Chinese medical journal, 107(9), 1994, pp. 648-652
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
0366-6999
Volume
107
Issue
9
Year of publication
1994
Pages
648 - 652
Database
ISI
SICI code
0366-6999(1994)107:9<648:EAPRIN>2.0.ZU;2-I
Abstract
Estrogen and progesterone receptors (ER, PR) were measured in 21 speci mens of cervical cancer and in 17 specimens of normal cervix by monocl onal enzyme immunoassay (EIA). In normal cervix, 88.2% of specimens we re ER-positive (>15 fmol/mg protein), 74.5% were PR-positive (>15 fmol /mg protein) and 74.5% were both ER- and PR-positive. In cervical canc er, 66.7% were ER-positive, 42.9% were PR-positive and 38.1% were both ER- and PR- positive. There was no significant difference in ER statu s between the normal cervix and cervical cancer (P>0.05), but PR statu s and levels in normal cervix were significantly higher than those in cervical carcinoma (P<0.05). ER levels in squamous cell carcinoma was not correlated to the tumor stage, histologic grade and menopausal sta tus. PR levels in premenopausal patients with squamous cell carcinoma were significantly higher than those in postmenopasual patients (P<0.0 1). Adenocarcinoma of the cervix contained significantly more ER and P R than squamous cell carcinoma (P<0.01, P<0.05). In addition, serum E2 level was also assayed in 21 patients with cervical cancer. There was significant difference in E2 levels between the premenopausal and pos tmenopausal patients (P<0.01). Patients were stratified according to E 2 levels, a significant difference in PR levels and in the ratio of PR /ER was noted (P<0.05, P<0.01).