THE UMPA GENE OF ESCHERICHIA-COLI ENCODES PHOSPHATIDYLGLYCEROL-PROLIPOPROTEIN DIACYLGLYCERYL TRANSFERASE (LGT) AND REGULATES THYMIDYLATE SYNTHASE LEVELS THROUGH TRANSLATIONAL COUPLING

Citation
Kd. Gan et al., THE UMPA GENE OF ESCHERICHIA-COLI ENCODES PHOSPHATIDYLGLYCEROL-PROLIPOPROTEIN DIACYLGLYCERYL TRANSFERASE (LGT) AND REGULATES THYMIDYLATE SYNTHASE LEVELS THROUGH TRANSLATIONAL COUPLING, Journal of bacteriology, 177(7), 1995, pp. 1879-1882
Citations number
14
Language
INGLESE
art.tipo
Note
Categorie Soggetti
Microbiology
Journal title
ISSN journal
0021-9193
Volume
177
Issue
7
Year of publication
1995
Pages
1879 - 1882
Database
ISI
SICI code
0021-9193(1995)177:7<1879:TUGOEE>2.0.ZU;2-Y
Abstract
Using a combination of biochemical, physical, and genetic techniques, we have shown that the umpA gene of Escherichia coli is allelic with t he lgt (phosphatidylglycerol:prolipoprotein diacylglyceryl transferase ) of Salmonella typhimurium. These genes are essential for the viabili ty of the respective organism and exhibit 92.8% sequence identity at t he amino acid level. In E. coli, lgt and thyA (thymidylate synthase) f orm an operon. Thymidylate synthase levels are regulated by transcript ion from the lgt promoter and by translational coupling.