PRESUMPTIVE PRESYNAPTIC NICOTINIC ACETYLCHOLINE-RECEPTORS IN THE CHICK TECTUM - EFFECTS OF LESIONS OF THE LATERAL SPIRIFORM NUCLEUS

Citation
As. Torrao et al., PRESUMPTIVE PRESYNAPTIC NICOTINIC ACETYLCHOLINE-RECEPTORS IN THE CHICK TECTUM - EFFECTS OF LESIONS OF THE LATERAL SPIRIFORM NUCLEUS, Brain research, 743(1-2), 1996, pp. 154-161
Citations number
63
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0006-8993
Volume
743
Issue
1-2
Year of publication
1996
Pages
154 - 161
Database
ISI
SICI code
0006-8993(1996)743:1-2<154:PPNAIT>2.0.ZU;2-X
Abstract
There are indications that nicotinic acetylcholine receptor subunits i n the superficial layers of the chick tectum (Cajal's layers 1-7) may be transported from the retina. However, nicotinic receptor subunits a re detectable by immunohistochemistry in all layers of the optic tectu m. In this study, we performed unilateral electrolytic lesions of the lateral spiriform nucleus, which projects to the deep layers of the te ctum and contains high amounts of nicotinic receptors in its perikarya . Following lesions of the lateral spiriform nucleus, both the alpha(5 ) and the beta(2) subunits were markedly depleted in the neuropil of t he deep layers of the ipsilateral optic tectum (layers 8-13). No chang es were observed in somata that contain either subunit. The present re sults suggest that most of the nicotinic acetylcholine receptor subuni ts in the chick optic tectum occur in axonal systems and could then co nstitute presynaptic receptors.