EVIDENCE FOR MEMBRANE REMODELING IN IPSILATERAL THALAMUS AND AMYGDALAFOLLOWING LEFT AMYGDALA-KINDLED SEIZURES IN AWAKE RATS

Citation
T. Arai et al., EVIDENCE FOR MEMBRANE REMODELING IN IPSILATERAL THALAMUS AND AMYGDALAFOLLOWING LEFT AMYGDALA-KINDLED SEIZURES IN AWAKE RATS, Brain research, 743(1-2), 1996, pp. 131-140
Citations number
59
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0006-8993
Volume
743
Issue
1-2
Year of publication
1996
Pages
131 - 140
Database
ISI
SICI code
0006-8993(1996)743:1-2<131:EFMRII>2.0.ZU;2-T
Abstract
We examined regional cerebral metabolic rates for glucose (rCMR(glc)) and brain incorporation coefficients (k) of each of three intravenous ly infused fatty acid radiotracers, [9,10-H-3]palmitate ([H-3]PAM), [1 -C-14]arachidonate ([C-14]AA) and [1-C-14]docosahexaenoate ([C-14]DHA) , in awake rats fully kindled by once-daily electrical stimulation of the left amygdala. Compared with sham-stimulated animals, rCMR(glc) wa s increased bilaterally during a seizure, particularly in midbrain-bra in stem regions, thalamus and basolateral nucleus of the amygdala. At 24 h and 2 weeks after a seizure, there was no significant change in k for either [C-14]AA or [C-14]DHA in any brain region, whereas k* for [H-3]PAM at 24 h was increased significantly (by 32-53%) ipsilateral to stimulation in regions of the amygdala and thalamus. Contralateral regions showed no significant change. Two weeks after a seizure, k fo r [3H]PAM was increased in the ipsilateral lateral dorsal nucleus of t he thalamus. These results argue for membrane remodeling involving pho sphatidylcholine in the ipsilateral amygdala and thalamus at the compl eted phase of amygdala kindling. Remodeling may continue for up to 2 w eeks after a seizure during the completed phase.