SYNERGISTIC INTERACTION BETWEEN AN ADENOSINE ANTAGONIST AND A D-1 DOPAMINE AGONIST ON ROTATIONAL BEHAVIOR AND STRIATAL C-FOS INDUCTION IN 6-HYDROXYDOPAMINE-LESIONED RATS

Citation
Ae. Pollack et Js. Fink, SYNERGISTIC INTERACTION BETWEEN AN ADENOSINE ANTAGONIST AND A D-1 DOPAMINE AGONIST ON ROTATIONAL BEHAVIOR AND STRIATAL C-FOS INDUCTION IN 6-HYDROXYDOPAMINE-LESIONED RATS, Brain research, 743(1-2), 1996, pp. 124-130
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
0006-8993
Volume
743
Issue
1-2
Year of publication
1996
Pages
124 - 130
Database
ISI
SICI code
0006-8993(1996)743:1-2<124:SIBAAA>2.0.ZU;2-Q
Abstract
The interaction between adenosine and D-1 dopamine systems in regulati ng motor behavior and striatal c-Fos expression was examined in rats w ith unilateral 6-hydroxydopamine (6-OHDA) lesions. These results were compared to the synergistic interaction between D-1 and D-2 dopamine s ystems in 6-OHDA rats. Coadministration of the adenosine antagonist 3, 7-dimethyl-1-propargylxanthine (DMPX: 10 mg/kg) and the D-1 dopamine a gonist SKF38393 (0.5 mg/kg) to 6-OHDA-lesioned rats produced significa nt contralateral rotation and c-Fos expression in the ipsilateral stri atum compared to 6-OHDA rats treated with either drug alone. However, the regional pattern of striatal c-Fos activation following treatment of 6-OHDA rats with SKF38393 and DMPX was different from the dorsolate ral pattern of striatal c-Fos induction observed after coadministratio n of D-1 and D-2 dopamine agonists (SKF38393: 0.5 mg/kg + quinpirole: 0.05 mg/kg). These data are consistent with a functional interaction b etween D-1 dopamine and adenosine systems in the striatum, but suggest that activation of different subsets of striatal neurons underlie the behavioral synergy observed following combined adenosine antagonist-D -1 dopamine agonist and combined D-1 dopamine agonist-D-2 dopamine ago nist treatment.