VASOPRESSIN RECEPTORS IN THE MOUSE (MUS MUSCULUS) BRAIN - SEX-RELATEDEXPRESSION IN THE MEDIAL PREOPTIC AREA AND HYPOTHALAMUS

Citation
M. Duboisdauphin et al., VASOPRESSIN RECEPTORS IN THE MOUSE (MUS MUSCULUS) BRAIN - SEX-RELATEDEXPRESSION IN THE MEDIAL PREOPTIC AREA AND HYPOTHALAMUS, Brain research, 743(1-2), 1996, pp. 32-39
Citations number
54
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0006-8993
Volume
743
Issue
1-2
Year of publication
1996
Pages
32 - 39
Database
ISI
SICI code
0006-8993(1996)743:1-2<32:VRITM(>2.0.ZU;2-6
Abstract
We have investigated the distribution of vasopressin binding sites in the brain of male and female adult mice using a radio-iodinated ligand and film autoradiography. Vasopressin receptors were uncovered in var ious regions of the brain including the basal nucleus of Meynert, the substantia innominata, the hypothalamic paraventricular nucleus, the s ubstantia nigra pars compacta and the hypoglossal nucleus. A sex-relat ed difference in the expression of vasopressin receptors was seen in t he medial preoptic area/anterior hypothalamus corresponding to the rat sexually dimorphic nucleus in the rat and in the hypothalamic mammill ary nuclei. In both structures the autoradiographic labeling is more i ntense in females than in males. These observations confirm that vasop ressin binding sites are present in the hypothalamic preoptic area of most species examined so far and that sex-related expression of neurop eptide receptors could trigger sex-related behavioral differences.