SERUM LEVELS OF CYTOKERATIN-19 FRAGMENTS IN CERVICAL-CANCER

Citation
K. Nasu et al., SERUM LEVELS OF CYTOKERATIN-19 FRAGMENTS IN CERVICAL-CANCER, Gynecologic and obstetric investigation, 42(4), 1996, pp. 267-270
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Obsetric & Gynecology
ISSN journal
0378-7346
Volume
42
Issue
4
Year of publication
1996
Pages
267 - 270
Database
ISI
SICI code
0378-7346(1996)42:4<267:SLOCFI>2.0.ZU;2-X
Abstract
Serum levels of a cytokeratin 19 fragment, Cyfra 21-1, were measured u sing an immunoradiometric assay in 33 women before initial treatment a nd in 8 women with recurrent tumor. The serum level of Cyfra 21-1 was significantly increased in women with tumors of advanced stage (FIGO) and those with recurrence. The incidence of positivity for Cyfra 21-1 tended to increase with tumor spread. Compared with squamous cell carc inoma (SCC) antigen, the sensitivity of Cyfra 21-1 was comparable to t hat of SCC antigen. The serum level of Cyfra 21-1 and that of SCC anti gen showed a positive correlation. While the use of the serum Cyfra 21 -1 level may be limited in cervical cancer by its relatively low sensi tivity, a combination assay of Cyfra 21-1 and SCC antigen may be usefu l in the diagnosis and follow-up of patients with cervical squamous ce ll carcinoma.