TREATMENT OF SYMPTOMATIC AMEBIC-COLITIS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PERSONS

Citation
K. Ohnishi et M. Murata, TREATMENT OF SYMPTOMATIC AMEBIC-COLITIS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PERSONS, International journal of antimicrobial agents, 7(4), 1996, pp. 231-233
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy
ISSN journal
0924-8579
Volume
7
Issue
4
Year of publication
1996
Pages
231 - 233
Database
ISI
SICI code
0924-8579(1996)7:4<231:TOSAIH>2.0.ZU;2-S
Abstract
While most Entamoeba histolytica appearing in male homosexuals infecte d with human immunodeficiency virus (HIV) is considered non-invasive i n Western countries, and treatment of amebiasis in these persons has r eceived very little attention, in Japan some male homosexual amebiasis patients infected with HIV complain of symptoms attributable to E. hi stolytica infection. We investigated whether symptomatic E histolytica amebic colitis in HIV-infected persons requires higher doses or longe r duration of antiamebic drug therapy than in non HIV-infected patient s. Four symptomatic amebic colitis patients infected with HIV-1, three of them severely immunocompromised, with CD4 cell counts <200/mm(3), were treated with oral metronidazole: 1500 mg a day for 10 days in 2 p atients, 1000 mg a day for 10 days in 1 patient, and 1000 mg a day for 6 days and then 750 mg for 4 days in 1 patient, and good therapeutic results with no side effects were obtained. This indicates that sympto matic amebic colitis in HIV-infected persons can be successfully treat ed with metronidazole at the same dose and duration of treatment used in non-HIV-infected persons. Copyright (C) 1996 Elsevier Science B.V.