A STUDY OF THE ASSOCIATION OF ALCOHOLISM WITH A1A2BO AND MNSS POLYMORPHISMS

Citation
Ic. Clemente et al., A STUDY OF THE ASSOCIATION OF ALCOHOLISM WITH A1A2BO AND MNSS POLYMORPHISMS, Alcohol and alcoholism, 29(6), 1994, pp. 711-714
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
29
Issue
6
Year of publication
1994
Pages
711 - 714
Database
ISI
SICI code
0735-0414(1994)29:6<711:ASOTAO>2.0.ZU;2-H
Abstract
Polymorphic variants of A1A2B0 and MNSs systems were analysed in a sam ple of 300 alcoholic patients subdivided according to gender and famil y history of alcoholism. There was agreement between observed and expe cted frequencies assuming genetic equilibrium. No association between phenotypes or genes of the A1A2B0 polymorphism and alcoholism was foun d when the Woolf method was used to evaluate possible associations. In the MNSs polymorphism, when the Woolf method was applied, significant values of chi(2) suggest a possible association between alcoholism an d this blood marker, but after Bonferroni correction this association was rejected.