GENETIC POLYMORPHISMS OF ALCOHOL METABOLIZING ENZYMES RELATED TO ALCOHOL SENSITIVITY AND ALCOHOLIC DISEASES

Authors
Citation
A. Yoshida, GENETIC POLYMORPHISMS OF ALCOHOL METABOLIZING ENZYMES RELATED TO ALCOHOL SENSITIVITY AND ALCOHOLIC DISEASES, Alcohol and alcoholism, 29(6), 1994, pp. 693-696
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
29
Issue
6
Year of publication
1994
Pages
693 - 696
Database
ISI
SICI code
0735-0414(1994)29:6<693:GPOAME>2.0.ZU;2-X
Abstract
Individuals with the atypical aldehyde dehydrogenase ALDH(2)(2) allele , both homozygous and heterozygous status, are alcohol sensitive and h ave a markedly reduced risk of developing alcoholic diseases. Genetic abnormalities of the ALDH(l) locus are also associated with alcohol fl ushing. The ALDH(3) and ALDH(x) loci are polymorphic and their variati ons may affect the development of alcoholic diseases. The variations o f alcohol dehydrogenase ADH(2) and ADH(3) loci have no profound effect s on alcohol sensitivity. The newly identified ADH(6) gene has hormone response elements, and it may cause the gender difference in alcoholi c problems.