EATING A MEAL INCREASES THE CLEARANCE OF ETHANOL GIVEN BY INTRAVENOUS-INFUSION

Citation
Rg. Hahn et al., EATING A MEAL INCREASES THE CLEARANCE OF ETHANOL GIVEN BY INTRAVENOUS-INFUSION, Alcohol and alcoholism, 29(6), 1994, pp. 673-677
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
29
Issue
6
Year of publication
1994
Pages
673 - 677
Database
ISI
SICI code
0735-0414(1994)29:6<673:EAMITC>2.0.ZU;2-Q
Abstract
We studied the effect of eating a meal an the rate of ethanol eliminat ion (clearance) from the blood after giving 0.4 g/kg by intravenous in fusion to six female and six male volunteers. Half of the subjects had eaten breakfast whereas the other half had fasted overnight. After th e first infusion of alcohol, those who had fasted ate lunch, and all t he volunteers received a second infusion with the same dose of ethanol . The blood ethanol concentration was measured repeatedly for up to 18 0-240 min after the start of each experiment. Intake of food (lunch or breakfast) increased the clearance of ethanol by about 60% (P < 0.001 ). Alcohol intoxication was less pronounced at the end of the ethanol infusions preceded by eating a meal (P < 0.01). Gender had no signific ant effect on the rate of ethanol elimination. We conclude that eating a meal increases the rate of ethanol elimination even when alcohol is given by intravenous infusion.