RELATIONSHIP BETWEEN GENETIC-POLYMORPHISM OF CYP2E1 AND ALDH2, AND POSSIBLE SUSCEPTIBILITY TO ALCOHOLISM

Citation
K. Iwahashi et al., RELATIONSHIP BETWEEN GENETIC-POLYMORPHISM OF CYP2E1 AND ALDH2, AND POSSIBLE SUSCEPTIBILITY TO ALCOHOLISM, Alcohol and alcoholism, 29(6), 1994, pp. 639-642
Citations number
8
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
29
Issue
6
Year of publication
1994
Pages
639 - 642
Database
ISI
SICI code
0735-0414(1994)29:6<639:RBGOCA>2.0.ZU;2-R
Abstract
In 45 healthy Japanese volunteers, it was found that persons heterozyg ous for ALDH2 (ALDH2(not asymptotic to)1/ALDH2(not asymptotic to)2), a nd also either heterozygous or mutant homozygous for CYP2E1 (C-2/C-2 o r C-1/C-2), can drink much more alcohol, even with (slight) flushing, than persons heterozygous for ALDH2 (ALDH2(not asymptotic to)1/ALDH2(n ot asymptotic to)2) and normal homozygous for CYP2E1 (C-1/C-1).