ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR BUT NOT CALCIUM BLOCKER DOWN-REGULATES GENE-EXPRESSION OF VASCULAR NATRIURETIC PEPTIDE RECEPTOR IN HYPERTENSIVE RATS
T. Yoshimoto et al., ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR BUT NOT CALCIUM BLOCKER DOWN-REGULATES GENE-EXPRESSION OF VASCULAR NATRIURETIC PEPTIDE RECEPTOR IN HYPERTENSIVE RATS, Biochemical and biophysical research communications, 205(3), 1994, pp. 1595-1600
We have recently found that vascular natriuretic peptide (NP)-A recept
or mRNA is upregulated in genetically hypertensive (SHR-SP/Izm) and de
oxycorticosterone acetate (DOCA)-salt hypertensive rats. In the presen
t study, we examined the effects of antihypertensive treatments on aor
tic NP-A receptor mRNA expression in these hypertensive rats using rib
onuclease protection assay. Oral administration of an angiotensin conv
erting enzyme inhibitor, derapril, but not a calcium channel blocker,
manidipine, produced a significant decrease of the NP-A receptor mRNA
level after 4 weeks, while both antihypertensive agents showed similar
hypotensive effects. Plasma renin was high in SHR-SP/Izm and low in D
OCA-salt rats. These results suggest that the vascular renin-angiotens
in system rather than the blood pressure has an important role in the
regulation of the vascular NP-A receptor. (C) 1994 Academic Press, Inc
.