ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR BUT NOT CALCIUM BLOCKER DOWN-REGULATES GENE-EXPRESSION OF VASCULAR NATRIURETIC PEPTIDE RECEPTOR IN HYPERTENSIVE RATS

Citation
T. Yoshimoto et al., ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR BUT NOT CALCIUM BLOCKER DOWN-REGULATES GENE-EXPRESSION OF VASCULAR NATRIURETIC PEPTIDE RECEPTOR IN HYPERTENSIVE RATS, Biochemical and biophysical research communications, 205(3), 1994, pp. 1595-1600
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,Biophysics
ISSN journal
0006-291X
Volume
205
Issue
3
Year of publication
1994
Pages
1595 - 1600
Database
ISI
SICI code
0006-291X(1994)205:3<1595:AEBNCB>2.0.ZU;2-T
Abstract
We have recently found that vascular natriuretic peptide (NP)-A recept or mRNA is upregulated in genetically hypertensive (SHR-SP/Izm) and de oxycorticosterone acetate (DOCA)-salt hypertensive rats. In the presen t study, we examined the effects of antihypertensive treatments on aor tic NP-A receptor mRNA expression in these hypertensive rats using rib onuclease protection assay. Oral administration of an angiotensin conv erting enzyme inhibitor, derapril, but not a calcium channel blocker, manidipine, produced a significant decrease of the NP-A receptor mRNA level after 4 weeks, while both antihypertensive agents showed similar hypotensive effects. Plasma renin was high in SHR-SP/Izm and low in D OCA-salt rats. These results suggest that the vascular renin-angiotens in system rather than the blood pressure has an important role in the regulation of the vascular NP-A receptor. (C) 1994 Academic Press, Inc .