DOSE-EFFECT RELATIONSHIP FOR IN-VIVO AND IN-VITRO INDUCTION OF DICENTRIC ABERRATIONS IN BLOOD-LYMPHOCYTES OF CHILDREN

Citation
A. Leonard et al., DOSE-EFFECT RELATIONSHIP FOR IN-VIVO AND IN-VITRO INDUCTION OF DICENTRIC ABERRATIONS IN BLOOD-LYMPHOCYTES OF CHILDREN, Radiation research, 141(1), 1995, pp. 95-98
Citations number
16
Language
INGLESE
art.tipo
Note
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
ISSN journal
0033-7587
Volume
141
Issue
1
Year of publication
1995
Pages
95 - 98
Database
ISI
SICI code
0033-7587(1995)141:1<95:DRFIAI>2.0.ZU;2-1
Abstract
Chromosome aberrations induced in vivo were studied in nine children 5 -12 years old treated with total-body high-energy photon irradiation ( pulsed exposure from a LINAC) for different types of malignant disease s. Dose-effect relationships were obtained for each child by taking br ood at different times during exposure. In vitro dose-effect relations hips for chromosome aberrations in children and adults were obtained b y exposing blood under the same conditions as the children. Exposure i n vivo and in vitro yielded similar linear-quadratic dose-effect relat ionships for dicentric aberrations. The response in vitro was slightly greater than in vivo, but the difference was not very large. It is co ncluded that the dose-effect relationship for dicentric chromosome abe rrations obtained in vitro for adults can be used for biological dosim etry in irradiated children. Some of the children displayed a high num ber of ''rogue cells'' before exposure; this may be due to the maligna nt disease as it was not found in the healthy controls.