IRON PIRACY - ACQUISITION OF TRANSFERRIN-BOUND IRON BY BACTERIAL PATHOGENS

Citation
Cn. Cornelissen et Pf. Sparling, IRON PIRACY - ACQUISITION OF TRANSFERRIN-BOUND IRON BY BACTERIAL PATHOGENS, Molecular microbiology, 14(5), 1994, pp. 843-850
Citations number
71
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Biology,Microbiology
Journal title
ISSN journal
0950-382X
Volume
14
Issue
5
Year of publication
1994
Pages
843 - 850
Database
ISI
SICI code
0950-382X(1994)14:5<843:IP-AOT>2.0.ZU;2-U
Abstract
The mechanism of iron utilization from transferrin has been most exten sively characterized in the pathogenic Neisseria species and Haemophil us species. Two transferrin-binding proteins, Tbp1 and Tbp2, have been identified in these pathogens and are thought to be components of the transferrin receptor. Tbp1 appears to be an integral, Tone-dependent outer membrane protein while Tbp2, a lipoprotein, may be peripherally associated with the outer membrane. The relative contribution of each of these proteins to transferrin binding and utilization is discussed and a model of iron uptake from transferrin is presented. Sequence com parisons of the genes encoding neisserial transferrin-binding proteins suggest that they are probably under positive selection for variation and may have resulted from inter-species genetic exchange.